In Parkinson’s disease (PD) there are abnormalities in brain regions important in the control of voluntary movement. The purpose of this project is to learn the relationship between three of these brain regions: the basal ganglia, motor cortex, and cerebellum in PD patients who have undergone deep brain stimulation (DBS) treatment. DBS involves the implantation of electrodes (wires) into the basal ganglia. In our center, we externalize the DBS electrodes for a few days after surgery, providing a unique opportunity to record basal ganglia activity. We will also record signals from the motor cortex using electrodes placed on the scalp (EEG). These deep (basal ganglia) and surface (motor cortex) brain recordings will be compared before and after the cerebellum is temporarily shut down with a special kind of magnetic stimulation (called cTBS). The cerebellum is thought to be involved in tremor and to explore this relationship, we will measure arm movement changes in response to cerebellar cTBS. This study will improve our understanding of the role of the cerebellum in PD and may contribute to the development of new therapies to treat PD symptoms.

Highlights:

  • Parkinson’s disease is a motor circuit disorder characterized by abnormal oscillation synchrony.
  • The cerebellum is involved in motor control, but its role in PD symptoms is not well understood.
  • The cerebellum may be a therapeutic target for normalizing oscillation synchrony in PD.

Who is eligible to participate?

  • Patients undergoing DBS surgery, on the few days immediately after their procedure

What is required of the participant?

  • Spend about 2 hours in the lab, while we apply transcranial magnetic stimulation to the cerebellum, while simultaneously recording activity from the externalized DBS lead and monitoring surface EEG (electrodes applied to the scalp)

University of Calgary and Hotchkiss Brain Institute
REB 16-1654

 

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